Entecavir Monohydrate, Entecavir API CAS No: 209216-23-9

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Model NO.: API001
• Transport Package: Carton
• Specification: 99.9%
• Trademark: SCM Pioneering
• Origin: China
• HS Code: 29335990
• Production Capacity: 20kg/Year

Product Description

Entecavir Monohydrate CAS No: 209216-23-9

Product Description

Entecavir monohydrate is a new type of cyclovaleryl guanosine anti hepatitis B virus drug. Its pharmacological action is similar to that of Entecavir. It is clinically applicable to the treatment of chronic adult hepatitis B with active virus replication, continuous elevation of serum aminotransferase ALT, or liver histology showing active lesions.

Test items	Acceptance criteria		Result
Description	White to off-white powder		White powder
Identification	1)The IR absorption spectrum of the sample must be concordant with entecavir 2) RT of the sample should match that of standardin assay preparation		Conform Conform
Water	5.8%-6.5%		6.2%
Optical rotation	+24.0°-+28.0°(DMF:MeOH=1:1 c=1%)		+26.6°
Residue on ignition	≤0.1%		0.09%
Heavy metals	≤20ppm		<20ppm
Related Substances	Total impurities ≤0.3% Any individual impurity ≤0.1%		0.12 0.02%
Assay(HPLC)	98.0% -102.0%( on anhydrous basis)		100.0%
Residual solvents	dic-hloromethane≤600ppm meth-anol≤3000ppm ethyl-acetate≤5000ppm tol-uene≤890ppm		not detected  not detected  not detected not detected
Conclusion: conform

 

Application

Entecavir, a nucleoside analogue of guanine, has an inhibitory effect on hepatitis B virus (HBV) polymerase. It can be converted into active triphosphate through phosphorylation. The half-life of triphosphate in cells is 15 hours. The natural substrate competes with the deoxyguanosine triphosphate of HBV polymerase, and entecavir triphosphate can inhibit all three activities of viral polymerase (reverse transcriptase):

(1) HBV polymerase promoter;
(2) Before the formation of reverse transcriptional negative chain synthesis of genomic mRNA;
(3) HBV DNA is a strand.

Can be applied to:
Treat hepatitis B infection. Helps prevent hepatitis B virus from multiplying and infecting new hepatocytes. Entecavir is also used to treat chronic hepatitis B infected with HIV/AIDS in adults.

Free Samples

Free of charge.
We are ready to provide samples for you test, normally 20g/bag.

Packaging & Shipping

 

Standard export packing (25kg per bag).

As per customer's request

 

Company Profile

SCM Pioneering Co., Ltd is an emerging supplier of high quality ingredients which based in Shandong province, China.

SCM was established by group of experts who have more than ten years experiences in pharmaceutical and food ingredients industries. with our deep knowledge and diligence, together with our associated plants, we would like to provide one-stop sourcing solutions for customers, to save your time and secure your purchasing.
 

 

 

 

FAQ

1.What are the suitable populations for Entecavir monohydrate?
Entecavir monohydrate has obvious auxiliary effect on the treatment of chronic hepatitis B, and is mainly suitable for people with chronic hepatitis B.

2.Can I get some sample for test?

Sure, we can supply samples free for your test. Normally 10g to 20g is enough.
 

3.Is NMN suitable for long-distance ocean transport?
Yes. We understand your concern. The Entecavir monohydrate will be packed in 1kg Aluminum foil bag, and 25KG carton box,  then tray wrapped film, which is suitable for long-distance land and sea transportation. When shipping, we will apply for positions below the water level.

4.How can you guarantee the quality?
We have regular factory inspection to view the production status. And compare all qualified batches to select the best one for our customer before delivery.

5.When can you deliver goods if we confirm the order?
We will arrange the latest production batch for you, within seven days.

Dear friends, now contact us to get more benefit!